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For example, myoclonic epilepsy withragged red fibers (MERRF) is characterized by muscleweakness, ataxia, seizures, and cardiac and respiratory failure.Microscopic examination of muscle tissue from affected pa-tients shows aggregates ofabnormal mitochondria, providinga ragged appearance of red muscle fibers. In contrast to other types ofintermediate filaments found in the cytoplasm order Lyrica online lamins arelocated within the nucleoplasm ofalmost all differentiatedcells in the body.

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